PBT 1033 (Standard)

PBT 1033 (Standard) is the analytical standard of PBT 1033. This product is intended for research and analytical applications. PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD) . PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2].

Product Specifications

CAS Number

[747408-78-2]

Product Name Alternative

PBT 2 (Standard)

UNSPSC

12352005

Target

Bacterial; Reference Standards

Related Pathways

Anti-infection; Others

Field of Research

Neurological Disease

Smiles

ClC1=CC(Cl)=C(O)C2=C1C=CC(CN(C)C)=N2

Molecular Formula

C12H12Cl2N2O

Molecular Weight

271.15

References & Citations

[1]Faux NG, et al. PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. J Alzheimers Dis. 2010;20 (2) :509-16. |[2]Harbison-Price N, et al. Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2. mSphere. 2020 Mar 18;5 (2) :e00157-20. |[3]Johanssen T, et al. PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning. Neurobiol Dis. 2015 Sep;81:176-85. |[4]Crouch PJ, et al. The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity. J Neurochem. 2011 Oct;119 (1) :220-30. |[5]Adlard PA, et al. Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease. PLoS One. 2011 Mar 11;6 (3) :e17669.