Pamapimod (Standard)

Pamapimod (Standard) is the analytical standard of Pamapimod. This product is intended for research and analytical applications. Pamapimod (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod has no activity against p38δ or p38γ isoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment[1].

Product Specifications

CAS Number

[449811-01-2]

Product Name Alternative

Ro4402257 (Standard) ; R1503 (Standard)

UNSPSC

12352005

Target

Autophagy; p38 MAPK; Reference Standards

Related Pathways

Autophagy; MAPK/ERK Pathway; Others

Field of Research

Inflammation/Immunology

Smiles

O=C1C(OC2=CC=C(F)C=C2F)=CC3=CN=C(NC(CCO)CCO)N=C3N1C

Molecular Formula

C19H20F2N4O4

Molecular Weight

406.38

References & Citations

[1]Hill, R. J. et al. Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity. The Journal of pharmacology and experimental therapeutics 327, 610-619, doi:10.1124/jpet.108.139006 (2008) .