Losmapimod (Standard)

Losmapimod (Standard) is the analytical standard of Losmapimod. This product is intended for research and analytical applications. Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively[1].

Product Specifications

CAS Number

[585543-15-3]

Product Name Alternative

GSK-AHAB (Standard) ; GW856553X (Standard) ; SB856553 (Standard)

UNSPSC

12352005

Target

Autophagy; p38 MAPK; Reference Standards

Related Pathways

Autophagy; MAPK/ERK Pathway; Others

Field of Research

Inflammation/Immunology; Cancer

Smiles

CC1=C(C2=NC=C(C(NCC(C)(C)C)=O)C=C2)C=C(C(NC3CC3)=O)C=C1F

Molecular Formula

C22H26FN3O2

Molecular Weight

383.46

References & Citations

[1]Willette RN, et al. Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. J Pharmacol Exp Ther. 2009 Sep;330 (3) :964-70.|[2]Zhang XM, et al. Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition. Neurochem Int. 2015 Nov;90:1-8.