8-Chloroadenosine (Standard)

8-Chloroadenosine (Standard) is the analytical standard of 8-Chloroadenosine. This product is intended for research and analytical applications. 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice[1].

Product Specifications

CAS Number

[34408-14-5]

Product Name Alternative

8-Cl-Ado (Standard)

UNSPSC

12352005

Target

AMPK; Autophagy; Nucleoside Antimetabolite/Analog; Reference Standards

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics; Others; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2Cl)O[C@@H]1CO

Molecular Formula

C10H12ClN5O4

Molecular Weight

301.69

References & Citations

[1]Christine M Stellrecht, et al. ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells. J Hematol Oncol. 2014 Mar 14;7:23.