EIPA (Standard)

EIPA (Standard) is the analytical standard of EIPA. This product is intended for research and analytical applications. EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3) . EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[1154-25-2]

Product Name Alternative

L593754 (Standard) ; MH 12-43 (Standard) ; Ethylisopropylamiloride (Standard)

UNSPSC

12352005

Target

Autophagy; COX; Na+/H+ Exchanger (NHE) ; Prostaglandin Receptor; Reference Standards; TRP Channel

Related Pathways

Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(C1=NC(Cl)=C(N(CC)C(C)C)N=C1N)NC(N)=N

Molecular Formula

C11H18ClN7O

Molecular Weight

299.76

References & Citations

[1]Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72 (6) :1576-85.|[2]Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42 (6) :2418-2429.|[3]Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis.|[4]E V Stelmashook, et al. Acidosis and 5- (N-ethyl-N-isopropyl) amiloride (EIPA) Attenuate Zinc/Kainate Toxicity in Cultured Cerebellar Granule Neurons. Biochemistry (Mosc) . 2015 Aug;80 (8) :1065-72. |[5]Shigekuni Hosogi, et al. An inhibitor of Na (+) /H (+) exchanger (NHE), ethyl-isopropyl amiloride (EIPA), diminishes proliferation of MKN28 human gastric cancer cells by decreasing the cytosolic Cl (-) concentration via DIDS-sensitive pathways. Cell Physiol Biochem. 2012;30 (5) :1241-53.|[6]Junji Yamashita, et al. Role of Na+/H+ exchanger in the pathogenesis of ischemic acute renal failure in mice. J Cardiovasc Pharmacol. 2007 Mar;49 (3) :154-60. |[7]Fumitaka Kamachi, et al. Inhibition of lipopolysaccharide-induced prostaglandin E2 production and inflammation by the Na+/H+ exchanger inhibitors. J Pharmacol Exp Ther. 2007 Apr;321 (1) :345-52.