CGP 12177

CGP 12177 ((±) -CGP 12177) is a β-Adrenergic receptor (β-AR) ligand. CGP 12177 is a β3-AR (Ki = 88 nM) agonist with β1/β2-AR (Ki = 0.9 nM for β1; Ki = 4 nM for β2) antagonist action. CGP 12177 exhibits partial agonist properties for α1-AR in rat pulmonary artery. CGP 12177 regulates the expression of ucp and leptin genes in NMRI mice adipose tissues. CGP 12177 can be used for cardiovascular and metabolic disease research[1][2][3][4].

Product Specifications

CAS Number

[81047-99-6]

Product Name Alternative

(±) -CGP 12177

UNSPSC

12352005

Target

Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Metabolic Disease

Solubility

10 mM in DMSO

Smiles

O=C1NC2=C(OCC(O)CNC(C)(C)C)C=CC=C2N1

Molecular Formula

C14H21N3O3

Molecular Weight

279.33

References & Citations

[1]Leblais V, et al. Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery. J Pharmacol Exp Ther. 2004 Apr;309 (1) :137-45.|[2]Baker JG, et al. Pharmacological characterization of CGP 12177 at the human beta (2) -adrenoceptor. Br J Pharmacol. 2002 Oct;137 (3) :400-8.|[3]Oliver P, et al. In vivo effects of CGP-12177 on the expression of leptin and uncoupling protein genes in mouse brown and white adipose tissues. Int J Obes Relat Metab Disord. 2000 Apr;24 (4) :423-8.|[4]Strosberg AD, et al. Function and regulation of the beta 3-adrenoceptor. Trends Pharmacol Sci. 1996 Oct;17 (10) :373-81.