β-Funaltrexamine (hydrochloride)

β-Funaltrexamine (β-FNA) hydrochloride is a selective μ opioid receptor antagonist. β-Funaltrexamine hydrochloride also inhibits cytokine-induced iNOS activation. β-Funaltrexamine hydrochloride inhibits neuroinflammation and ameliorated neuronal degeneration. β-Funaltrexamine hydrochloride has anti-inflammatory and neuroprotective effects and can be used for research of neurodegenerative diseases (eg: stroke) [1][2]

Product Specifications

CAS Number

[72786-10-8]

Product Name Alternative

β-FNA (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NO Synthase; Opioid Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Purity

99.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@]1([C@@]2([H])CC3=CC=C4O)[C@@]5(CCN2CC6CC6)C3=C4O[C@@]5([H])[C@H](NC(/C=C/C(OC)=O)=O)CC1.Cl

Molecular Formula

C25H31ClN2O6

Molecular Weight

490.98

Precautions

H302, H315, H319, H335

References & Citations

[1]Wu CC, et al. β-Funaltrexamine Displayed Anti-inflammatory and Neuroprotective Effects in Cells and Rat Model of Stroke. Int J Mol Sci. 2020 May 29;21 (11) :3866.|[2]Ward SJ, et al. Pharmacological profiles of beta-funaltrexamine (beta-FNA) and beta-chlornaltrexamine (beta-CNA) on the mouse vas deferens preparation. Eur J Pharmacol. 1982 Jun 4;80 (4) :377-84.