HCH6-1 (Standard)

HCH6-1 (Standard) is the analytical standard of HCH6-1 (HY-101283) . This product is intended for research and analytical applications. HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1) . HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist) . HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases[1].

Product Specifications

CAS Number

[1435265-06-7]

Target

Formyl Peptide Receptor (FPR) ; Reference Standards

Related Pathways

GPCR/G Protein; Others

Field of Research

Inflammation/Immunology

Smiles

O=C(N[C@H](C(N[C@@H](C(OC)=O)CC1=CC=CC=C1)=O)CC2=CNC3=C2C=CC=C3)C4=CC=CC=C4

Molecular Formula

C28H27N3O4

Molecular Weight

469.53

References & Citations

[1]Yang SC, et al. Dipeptide HCH6-1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1. Free Radic Biol Med. 2017 May;106:254-269