PK7242
PK7242 is an inducer of reactivation of mutant p53 in cancer cells. In cancer cells carrying the Y220C mutant, PK7242 binds to the p53-Y220C core domain and induces growth inhibition, cell-cycle arrest, and apoptosis.
Product Specifications
CAS Number
[1446352-68-6]
UNSPSC
12352005
Target
MDM-2/p53
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
CN(C)CCN1N=C(N2C=CC=C2)C(C3=CC=C(F)C=C3)=C1
Molecular Formula
C17H19FN4
Molecular Weight
298.36
References & Citations
[1]Liu, X., Wilcken, R., Joerger, A.C., et al. Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Res. 41 (12), 6034-6044 (2013) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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