FCCP (Standard)

FCCP (Standard) is the analytical standard of FCCP. This product is intended for research and analytical applications. FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1].

Product Specifications

CAS Number

[370-86-5]

Product Name Alternative

Carbonyl cyanide 4- (trifluoromethoxy) phenylhydrazone (Standard)

UNSPSC

12352005

Target

Mitochondrial Metabolism; Oxidative Phosphorylation; PINK1/Parkin; Reference Standards

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Cancer

Smiles

N#C/C(C#N)=N/NC1=CC=C(OC(F)(F)F)C=C1

Molecular Formula

C10H5F3N4O

Molecular Weight

254.17

References & Citations

[1]Connop BP et al.Novel effects of FCCP [carbonyl cyanide p- (trifluoromethoxy) phenylhydrazone] on amyloid precursor protein processing. J Neurochem. 1999 Apr;72 (4) :1457-65.|[2]Tanpradit N, et al. Carbonyl cyanide 4- (trifluoromethoxy) phenylhydrazone (FCCP) pre-exposure ensures follicle integrity during in vitro culture of ovarian tissue but not during cryopreservation in the domestic cat model. J Assist Reprod Genet. 2016 Dec;33 (12) :1621-1631. Epub 2016 Sep 17.|[3]Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2 (5) :120080.