Bendroflumethiazide

Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus[1][2].

Product Specifications

CAS Number

[73-48-3]

Product Name Alternative

Bendrofluazide

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

NKCC

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bendroflumethiazide.html

Purity

99.16

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=S(C1=C(C(F)(F)F)C=C(C2=C1)NC(CC3=CC=CC=C3)NS2(=O)=O)(N)=O

Molecular Formula

C15H14F3N3O4S2

Molecular Weight

421.41

Precautions

H315, H319, H320

References & Citations

[1]Tamargo J, et al. Diuretics in the treatment of hypertension. Part 1: thiazide and thiazide-like diuretics. Expert Opin Pharmacother. 2014 Mar;15 (4) :527-47.|[2]Grønbeck L, et al. Mechanism of antidiuresis caused by bendroflumethiazide in conscious rats with diabetes insipidus. Br J Pharmacol. 1998 Feb;123 (4) :737-45.