PD146176

PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM) . PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice[1][2][3].

Product Specifications

CAS Number

[4079-26-9]

Product Name Alternative

NSC168807

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pd146176.html

Purity

99.59

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1(N2)=C(CSC3=CC=CC=C31)C4=C2C=CC=C4

Molecular Formula

C15H11NS

Molecular Weight

237.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Sendobry SM, et al. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br J Pharmacol. 1997;120 (7) :1199-1206.|[2]Bocan TM, et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit [published correction appears in Atherosclerosis 1998 Jul;139 (1) :201]. Atherosclerosis. 1998;136 (2) :203-216.|[3]Di Meco A, et al. 12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice. Biol Psychiatry. 2017;81 (2) :92-100.