ERK5-IN-5
ERK5-IN-5 (compound 4a) is an ERK5 kinase inhibitor with anticancer activity. ERK5-IN-5 exhibits good anti-proliferative activity with the IC50 value of 6.23 µg/mL for A549 cells[1].
Product Specifications
CAS Number
[2318792-30-0]
UNSPSC
12352005
Target
ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erk5-in-5.html
Purity
99.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CC=C(C2=CNC3=NC=CC=C32)CC1)C4=CC=C(Cl)C=C4
Molecular Formula
C19H16ClN3O
Molecular Weight
337.80
References & Citations
[1]Qin Zhang, et al. Design, synthesis and SAR of novel 7-azaindole derivatives as potential Erk5 kinase inhibitor with anticancer activity. Bioorg Med Chem. 2023 Oct 14:95:117503.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK5
Available Sizes
Curated Selection
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