Calcium dextrofolinate

Calcium dextrofolinate is a stereoisomer of Calcium folinate. Calcium folinate (Folinic acid calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].

Product Specifications

CAS Number

[115940-48-2]

Product Name Alternative

(6R) -Leucovorin (calcium) ; (6R) -Folinic acid (calcium)

UNSPSC

12352005

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/calcium-dextrofolinate.html

Purity

95.33

Solubility

H2O : 1.96 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCL; heat to 60°C)

Smiles

O=C([O-])CC[C@@H](C([O-])=O)NC(C1=CC=C(NC[C@H]2N(C=O)C3=C(N=C(N)NC3=O)NC2)C=C1)=O.[Ca+2]

Molecular Formula

C20H21CaN7O7

Molecular Weight

511.50

References & Citations

[1]Shui-Jie Shen, et al. [Direct resolution of calcium folinate stereoisomers using a bovine serum albumin chiral HPLC column]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 Jan;33 (1) :11-4.|[2]Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397 (2) :221-8.