CRTh2 antagonist 4
Product Specifications
UNSPSC Description
CRTh2 antagonist 4 (compound 58) is an inhibitor (IC50: 212 nM) of TH2 lymphocyte (CRTH2 or DP2) receptor with high binding affinity (Ki= 37 nM). CRTh2 antagonist 4 can be used in the study of severe allergic diseases[1].
Target Antigen
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/crth2-antagonist-4.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CN1C(C2(C(N(CC3=CC=CC=C3F)C(C2)=O)=O)C4=C1C=CC(Cl)=C4)=O
Molecular Weight
416.79
References & Citations
[1]Crosignani S, et al. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. J Med Chem. 2008 Apr 10;51(7):2227-43.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116890/CRTh2-antagonist-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116890/
Clinical Information
No Development Reported
CAS Number
916046-55-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6191882-01 0.1 mL
PLXNA2 (Plexin A2, KIAA0463, OCT, PLXN2, Plexin-A2, Semaphorin Receptor OCT, FLJ11751, FLJ30634) (MaxLight 405)
Ask
View Details MBS6191882-02 5x 0.1 mL
PLXNA2 (Plexin A2, KIAA0463, OCT, PLXN2, Plexin-A2, Semaphorin Receptor OCT, FLJ11751, FLJ30634) (MaxLight 405)
Ask
View Details 
MBS1154303-01 0.02 mg (E-Coli)
Recombinant Bacillus subtilis Uncharacterized protein yqkK (yqkK)
Ask
View Details 
MBS1154303-02 0.1 mg (E-Coli)
Recombinant Bacillus subtilis Uncharacterized protein yqkK (yqkK)
Ask
View Details MBS1154303-03 0.02 mg (Yeast)
Recombinant Bacillus subtilis Uncharacterized protein yqkK (yqkK)
Ask
View Details MBS1154303-04 0.1 mg (Yeast)
Recombinant Bacillus subtilis Uncharacterized protein yqkK (yqkK)
Ask
View Details