GPI-1046
Product Specifications
UNSPSC Description
GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models[1]. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models[2]. GPI-1046 improves HIV-associated injury of peripheral nerves[3].
Target Antigen
FKBP; HIV
Type
Reference compound
Related Pathways
Anti-infection;Apoptosis;Autophagy;Cell Cycle/DNA Damage;Immunology/Inflammation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gpi-1046.html
Purity
99.74
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(OCCCC1=CC=CN=C1)[C@H]2N(C(C(C(C)(C)CC)=O)=O)CCC2
Molecular Weight
360.45
References & Citations
[1]Sari Y, et al. Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats. Neuroscience. 2012 Dec 27;227:327-35.|[2]Eberling JL, et al. The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys. Exp Neurol. 2002 Dec;178(2):236-42.|[3]Scott Letendre, et al. Neurologic Complications of HIV Disease and Their Treatment. Top HIV Med. Apr-May 2007;15(2):32-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124619/GPI-1046-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124619/GPI-1046-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
186452-09-5
Available Sizes
Curated Selection
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