L-Azidohomoalanine
Product Specifications
UNSPSC Description
L-Azidohomoalanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. L-Azidohomoalanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Target Antigen
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-azidohomoalanine.html
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@@H](N)CCN=[N+]=[N-]
Molecular Weight
144.13
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.Microbiol Spectr. 2021 Nov 10;9(3):e0109421.|Cell Biosci. 2022 Dec 21;12(1):206.|Nat Commun. 2024 Jun 28;15(1):5481.|Redox Biol. 2022 Mar 24;52:102284.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-140346/L-Azidohomoalanine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-140346/
Clinical Information
No Development Reported
CAS Number
120042-14-0
Available Sizes
Curated Selection
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