PQR514
Product Specifications
UNSPSC Description
PQR514 is a potent PI3K inhibitor with anticancer activity. PQR514 is able to inhibit cancer cell proliferation. PQR514 showed significant antitumor activity in the OVCAR-3 xenograft model, with the required concentration being approximately one-eighth that of PQR309. PQR514 has good pharmacokinetic properties and minimal brain penetration, making it an optimized candidate compound for inhibiting systemic tumors[1].
Target Antigen
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/pqr514.html
Smiles
FC(C1=NC(N)=NC=C1C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)F
Molecular Weight
394.38
References & Citations
[1]Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl-Pyrimidine Moiety
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-167876/PQR514-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-167876/
Clinical Information
No Development Reported
CAS Number
1927857-55-3
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