SKI-I
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM) . SKI-I induces apoptosis in tumor cell lines[1][2].
Product Specifications
CAS Number
[306301-68-8]
Product Name Alternative
Rebemadlin
UNSPSC
12352005
Target
Apoptosis; SphK
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ski-i.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NNC(C2=CC=C3C=CC=CC3=C2)=C1)N/N=C/C4=C5C=CC=CC5=CC=C4O
Molecular Formula
C25H18N4O2
Molecular Weight
406.44
References & Citations
[1]French KJ, et, al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63 (18) :5962-9.|[2]Sharma AK, et, al. Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. Eur J Med Chem. 2010 Sep;45 (9) :4149-56.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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