SKI-I
Product Specifications
Product Name Alternative
Rebemadlin
UNSPSC Description
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines[1][2].
Target Antigen
Apoptosis; SphK
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ski-i.html
Purity
99.14
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NNC(C2=CC=C3C=CC=CC3=C2)=C1)N/N=C/C4=C5C=CC=CC5=CC=C4O
Molecular Weight
406.44
References & Citations
[1]French KJ, et, al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63(18):5962-9.|[2]Sharma AK, et, al. Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. Eur J Med Chem. 2010 Sep;45(9):4149-56.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115735/SKI-I-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115735/SKI-I-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
306301-68-8
Available Sizes
Curated Selection
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