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PROTAC MDM2 Degrader-3

PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase[1].

Product Specifications

CAS Number

[2249750-23-8]

UNSPSC

12352005

Target

E1/E2/E3 Enzyme; MDM-2/p53; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-mdm2-degrader-3.html

Purity

95.01

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C(N1CC(N(CC(OCCOCCOCCOCCOC(CN2C(CN(C(N3[C@H](C4=CC=C(Cl)C=C4)[C@H](C5=CC=C(Cl)C=C5)N=C3C6=C(C=C(OC)C=C6)OC(C)C)=O)CC2)=O)=O)=O)CC1)=O)N7[C@H](C8=CC=C(Cl)C=C8)[C@H](C9=CC=C(Cl)C=C9)N=C7C%10=C(C=C(OC)C=C%10)OC(C)C

Molecular Formula

C72H78Cl4N8O15

Molecular Weight

1437.25

References & Citations

[1]Method of inducing of self-degradation of MDM2 using E3 ubiquitin ligase dimer amide small molecule PROTACs. CN108610333A.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MDM2

Available Sizes

Curated Selection

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