Lenalidomide-OH

Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137) [1].

Product Specifications

CAS Number

[1416990-08-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lenalidomide-oh.html

Purity

99.48

Solubility

DMSO : 13.89 mg/mL (ultrasonic)

Smiles

O=C(C(N(CC1=C2C=CC(O)=C1)C2=O)CC3)NC3=O

Molecular Formula

C13H12N2O4

Molecular Weight

260.25

Precautions

H315, H319, H335

References & Citations

[1]Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30 (3) :126877.