IKFQFHFD

IKFQFHFD is a pH-responsive self-assembling peptide. It exhibits biocompatibility at neutral pH and adopts an antimicrobial peptide-like molecular structure only at acidic pH. IKFQFHFD can be used to treat chronic wounds caused by biofilm infections, such as venous ulcers, diabetic ulcers, and pressure sores.

[C@@H](CC1=CN=CN1)(NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)CCCCN)=O)=O)CCC(N)=O)=O)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O