DL-Acetylshikonin

DL-Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A (2) membrane recruitment via the decrease in [Ca (2+) ] (i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.