MK-8245 analog
Product Specifications
UNSPSC Description
MK-8245 analog (compound 6) is a potent stearoyl-CoA desaturase (SCD) inhibitor with an IC50 of 7 nM for rat SCD. MK-8245 analog has antidiabetic and antidyslipidemic effects[1].
Target Antigen
Stearoyl-CoA Desaturase (SCD)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mk-8245-analog.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CN1N=C(C2=NN=C(N3CCC(OC4=CC(F)=CC=C4Br)CC3)S2)N=N1
Molecular Weight
484.30
References & Citations
[1]Renata M Oballa, et al. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem. 2011 Jul 28;54(14):5082-96.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114184/MK-8245-analog-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114184/
Clinical Information
No Development Reported
CAS Number
1030612-87-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
