Si5-N14
Product Specifications
CAS Number
3006860-57-4
Target
FGFR|||Liposome|||VEGFR
Related Pathways
Angiogenesis|||Metabolism|||Tyrosine Kinase/Adaptors
Bioactivity
Si5-N14 is a key component of siloxane-linked lipid nanoparticles (SiLNP) with properties that enhance vascular repair and exhibit antitumor activity. In transgenic GFP mouse models, Si5-N14 mediates CRISPR-Cas9 editing. In Lewis lung carcinoma (LLC) tumor mouse models, it leads to the knockdown of vascular endothelial growth factor receptor 2 (VEGFR2), producing antitumor effects. Additionally, in mice with virus-induced lung injury, Si5-N14 facilitates the delivery of fibroblast growth factor-2 (FGF-2) mRNA, promoting vascular repair, oxygenation, and improved lung function. Si5-N14 shows potential for research in tumors, pneumonia, and cardiovascular diseases.
Smiles
O=C(NCCCCCCCCCCCCCC)CCN(CCC(=O)NCCCCCCCCCCCCCC)CCC[Si](O[Si](C)(C)CCCN(CCC(=O)NCCCCCCCCCCCCCC)CCC(=O)NCCCCCCCCCCCCCC)(C)C
Molecular Formula
C78H160N6O5Si2
Molecular Weight
1318.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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