SAR228810

SAR228810 is a humanized IgG4 monoclonal antibody inhibitor targeting amyloid beta (A?), with a dissociation constant (KD) of 0.43 nM for fibrillar A?, which is higher than for monomeric A?. It significantly hinders brain amyloid plaque formation, oligomer-induced synaptic dysfunction, and neuronal loss. Furthermore, SAR228810 offers substantial protection against A?-mediated neurotoxicity. MINT1526A is applicable in Alzheimer's disease imaging and immunotherapy research.