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NPD10084

Product Specifications

CAS Number

1040706-91-9

Target

PKM

Related Pathways

Metabolism

Bioactivity

NPD10084 is an inhibitor of pyruvate kinase PKM2 that blocks non-glycolytic signaling in cancer cells by disrupting PKM2's interaction with ?-catenin or STAT3, thus inhibiting downstream pathways. It demonstrates antiproliferative effects against colorectal cancer cells both in vitro and in vivo [1].

Smiles

C(=O)(N1CC=2C=3C(NC2CC1)=CC=CC3)C4=CC=5C(N4)=CC=CC5OC

Molecular Formula

C21H19N3O2

Molecular Weight

345.39

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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