NIC-12

Product Specifications

CAS Number

2409826-23-7

Target

NOD-like Receptor (NLR)

Related Pathways

Immunology/Inflammation

Bioactivity

NIC-12, a potent NLRP3 inhibitor, selectively reduces circulating IL-1ß levels in the LPS-endotoxemia mice model and inhibits NLRP3 inflammasome activation in mouse macrophages [1].

Smiles

C(C)(C)C=1N2C3=C(C=C2C(=O)N(CC(N[C@H]4CN(CC5CC5)CCC4)=O)N1)SC(Cl)=C3

Molecular Formula

C22H28ClN5O2S

Molecular Weight

462.01

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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