N-desmethyl Regorafenib N-oxide
Product Specifications
Target
Drug Metabolite|||c-Kit|||Others|||Raf|||VEGFR
Related Pathways
Others|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Metabolism|||MAPK
Bioactivity
N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.
Smiles
O(C=1C=C(C(N)=O)N(=O)=CC1)C2=CC(F)=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2
Molecular Formula
C20H13ClF4N4O4
Molecular Weight
484.79
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/187269689322242141/T84977
CAS Number
835621-12-0
Available Sizes
Curated Selection
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