HA-14-1
Product Specifications
CAS Number
927635-64-1
Target
Others|||Bcl-2 Family
Related Pathways
Apoptosis|||Others
Bioactivity
HA-14-1, a small molecule, binds the surface pocket of Bcl-2 proteins (IC50= ~ 9 µM), including Bcl-xl and Bcl-W, and disrupts their interaction with the Bak peptide. This action induces apoptosis by activating Apaf-1 and caspase-9 and -3. Additionally, HA-14-1 effectively induces apoptosis in human acute myeloid leukemia (HL-60) cells, with a 50 µM concentration resulting in a 90% loss of cell viability.
Smiles
C(C(OCC)=O)(C#N)C1C=2C(OC(N)=C1C(OCC)=O)=CC=C(Br)C2
Molecular Formula
C17H17BrN2O5
Molecular Weight
409.2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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