EGFR/HER2/DHFR-IN-2
Product Specifications
Target
EGFR|||DHFR
Related Pathways
DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis|||Metabolism
Bioactivity
EGFR/HER2/DHFR-IN-2 (Compound 4b) is an inhibitor of EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 ?M, respectively, and exhibits anticancer activity, displaying IC50 values of 9.14, 7.33, 14.18, 24.87, 20.07, and 6.16 ?M in Hep G2, HeLa, HEp-2, HCT 116, PC-3, and MCF7 cancer cell lines, respectively; it also reduces the growth of breast cancer tumors [1].
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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