LB244
Product Specifications
Target
STING
Related Pathways
Immunology/Inflammation
Bioactivity
LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 ?M, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies have shown that LB244 exhibits limited oral activity in mice [1].
Smiles
O=C(N[C@@H](CCCCNC(C1=CC=C([N+]([O-])=O)O1)=O)C2=NC(C=CC=C3)=C3N2)C(C=C4)=CC=C4C5=CC=CC=C5
Molecular Formula
C30H27N5O5
Molecular Weight
537.57
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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