Aurora Kinases-IN-4
Product Specifications
CAS Number
2877011-84-0
Target
Aurora Kinase
Related Pathways
Cell Cycle/Checkpoint|||Chromatin/Epigenetic
Bioactivity
Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM. It inhibits cell proliferation in SJSA-1, MDA-MB-231, A549, and HeLa cell lines with IC50 values of 4.27, 1.54, 3.08, and 6.99 ?M, respectively. This compound is applicable in research concerning triple-negative breast cancer (TNBC) [1].
Smiles
N(C=1C2=C(N=C(N1)C3=CC=C(NC(C=C)=O)C=C3)C=C(C=C2)N4CCN(C)CC4)C5=NNC(C)=C5
Molecular Formula
C26H28N8O
Molecular Weight
468.55
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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