Bcl-2-IN-5
Product Specifications
CAS Number
2728752-20-1
Target
Others|||Bcl-2 Family
Related Pathways
Apoptosis|||Others
Bioactivity
Bcl-2-IN-5 is a potent BCL-2 inhibitor with inhibitory concentrations (IC50) of 0.12 nM, 0.14 nM, and 0.22 nM against wild type Bcl-2, Bcl-2 D103Y, and Bcl-2 G101V, respectively. It also suppresses cell growth in Bcl 2-G101V knock-in [RS4;11] cells, with IC50 values of 0.2 nM and 0.44 nM.
Smiles
COc1ccc(CN2CCN(C3CC4(C3)CN(C4)c3ccc(C(=O)NS(=O)(=O)c4ccc(NC[C@H]5CC[C@](C)(O)CC5)c(c4)N(=O)=O)c(Oc4cnc5[nH]cc(F)c5c4)c3)[C@@H](C2)c2ccccc2C(C)C)cc1
Molecular Formula
C55H63FN8O8S
Molecular Weight
1015.2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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