ZT55
Product Specifications
CAS Number
2138488-38-5
Target
Others|||Apoptosis|||JAK
Related Pathways
JAK/STAT signaling|||Angiogenesis|||Stem Cells|||Others|||Apoptosis|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors
Bioactivity
ZT55, an orally active, highly-selective JAK2 inhibitor with an IC50 of 0.031 ?M, inhibits proliferation of JAK2 V617F-expressing HEL cell lines, induces apoptosis and cycle arrest, and effectively inhibits HEL xenograft tumor growth in mice models. Suitable for studies on myeloproliferative neoplasms, polycythemia vera, and primary thrombocythemia, ZT55 offers promising applications.
Smiles
C(C(NC1=C(OC)C=CC=C1)=O)C=2C=3C(N(O)C2)=CC=CC3
Molecular Formula
C17H16N2O3
Molecular Weight
296.32
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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