I-138

Product Specifications

CAS Number

2098211-50-6

Target

DUB

Related Pathways

Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Ubiquitination

Purity

0.9941

Bioactivity

I-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.

Smiles

C(N1C=2C(NC1=O)=CN=C(N2)C3=C(C(C)C)C=CC=C3)C4=CC=C(C=C4)C5=NC(C(F)(F)F)=CN5C

Molecular Formula

C26H23F3N6O

Molecular Weight

492.5

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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