Febrifugine

Febrifugine is a quinazolinone alkaloid that inhibits P. falciparum and has antimalarial activity. Febrifugine inhibits bladder cancer by inhibiting DNA synthesis, inducing apoptosis, and reducing steroids[1][2][3].

Product Specifications

CAS Number

[24159-07-7]

UNSPSC

12352005

Hazard Statement

H301, H311, H331

Target

Apoptosis; DNA/RNA Synthesis; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/febrifugine.html

Purity

99.98

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1N(CC(C[C@H]2NCCC[C@@H]2O)=O)C=NC3=C1C=CC=C3

Molecular Formula

C16H19N3O3

Molecular Weight

301.34

Precautions

H301, H311, H331

References & Citations

[1]Herman JD, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20;7 (288) :288ra77.|[2]Murata K, et al. Potentiation by febrifugine of host defense in mice against Plasmodium berghei NK65. Biochem Pharmacol. 1999 Nov 15;58 (10) :1593-601.|[3]Chen J, et al. Discovery of anticancer function of Febrifugine: Inhibition of cell proliferation, induction of apoptosis and suppression steroid synthesis in bladder cancer cells. Toxicol Appl Pharmacol. 2024 Mar;484:116878.