Carotegrast methyl HCl
Product Specifications
CAS Number
1338380-52-1
Target
Integrin|||Others
Related Pathways
Others|||Cytoskeletal Signaling
Bioactivity
Carotegrast methyl, also known as AJM300 and PTC-100, is an orally-active small molecule that antagonises the ?4 integrin receptor. AJM300 reduces inflammation by blocking leucocyte trafficking. Oral treatment with AJM300 dose-dependently inhibited lymphocyte homing to Peyer's patches and increased the peripheral lymphocyte count in the same dose range. AJM300 dose-dependently prevented the development of experimental colitis in mice.
Smiles
Cl.COC(=O)[C@H](Cc1ccc(cc1)-n1c(=O)n(C)c2ccc(cc2c1=O)N(C)C)NC(=O)c1c(Cl)cccc1Cl
Molecular Formula
C25H20Cl3N3O5
Molecular Weight
548.801
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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