SB-284851-BT
Product Specifications
CAS Number
219769-23-0
Target
P38 MAPK|||Epigenetic Reader Domain|||Others
Related Pathways
Others|||MAPK|||Chromatin/Epigenetic
Bioactivity
SB-284851-BT is a chemical compound that serves as an inhibitor of BRD4, p38?, and BRDT, exhibiting varying degrees of affinity and inhibition for each. Specifically, it inhibits BRD4-BD1 with an IC50 value of 1.7 µM, p38? with a Kd of 0.47 nM, BRDT (1) with an IC50 value of 18 µM, and BRD4 (1) with an IC50 value of 3.7 µM. By targeting p38?, SB-284851-BT effectively reduces IL-8 production and, through inhibiting BRD4, down-regulates both the c-Myc and NF-?B gene pathways, crucial in cancer pathways. Additionally, SB-284851-BT is designed to combine with the bromine domain and extra terminal (BET) proteins.
Smiles
O(C=1N=C(C2=C(N=CN2C3CCNCC3)C4=CC=C(F)C=C4)C=CN1)C5=CC(C)=CC(C)=C5
Molecular Formula
C26H26FN5O
Molecular Weight
443.52
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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