SR1903 TFA

SR-1903 is a modulator of retinoic acid receptor-related orphan receptor ? (ROR?) and liver X receptor (LXR) . It is an inverse agonist of ROR? and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor ? (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1) . It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-1903 reduces the severity of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.