HI042
Product Specifications
CAS Number
898168-15-5
Target
Apoptosis|||FLT
Related Pathways
Angiogenesis|||Apoptosis|||Tyrosine Kinase/Adaptors
Bioactivity
HI042 is an FMS-like tyrosine kinase 3 (FLT3) inhibitor, showing an IC50 value of 0.62 ?M for MOLM-13 cells, 0.33 ?M for MV4-11 cells, and 0.89 ?M for OCI-AML3 cells. It selectively reduces the survival rate of FLT3-internal tandem duplication (FLT3-ITD) positive cell lines, induces apoptosis, disrupts cell cycle progression, and diminishes colony-forming ability. HI042 is applicable for acute myeloid leukemia (AML) research.
Smiles
O=C(C=CC=1C=CC=CC1)NN=CC=2SC(=CC2)N(=O)=O
Molecular Formula
C14H11N3O3S
Molecular Weight
301.32
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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