WZH-17-002
Product Specifications
Target
PROTACs|||Akt|||ERK|||ALK
Related Pathways
Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling|||Angiogenesis|||MAPK|||Tyrosine Kinase/Adaptors|||PROTAC
Bioactivity
WZH-17-002 is an ALKPROTAC degrader based on WZH-15-125, with a DC50 of 25 nM. This compound enhances the efficacy against ALK mutations that confer resistance to Lorlatinib. Moreover, WZH-17-002 significantly reduces resistance in ALK fusion non-small cell lung cancer (NSCLC) and inhibits tumor growth in EML4-ALK G1202R/L1196M xenograft mouse models.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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