PI3K/mTOR-IN-17
Product Specifications
Target
PI3K|||Apoptosis|||Caspase|||Bcl-2 Family|||MDM-2/p53|||mTOR
Related Pathways
Apoptosis|||PI3K/Akt/mTOR signaling|||Proteases/Proteasome
Bioactivity
PI3K/mTOR-IN-17 is a dual inhibitor that targets both PI3K and mTOR, with IC50 values of 1.21 ?M and 0.21 ?M, respectively. It induces apoptosis mediated by caspases and arrests cell growth in the G1 phase. The compound elevates the levels of caspases-3, 7, 8, and 9, enhances p53 expression, and increases the Bax/Bcl-2 ratio. By inhibiting the PI3K/mTOR signaling pathway, PI3K/mTOR-IN-17 is applicable in cancer research, including studies on non-small cell lung cancer (NSCLC) .
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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