KRAS IN-44
Product Specifications
Target
PDE|||PI3K|||Akt|||Apoptosis|||Ras|||mTOR
Related Pathways
Cytoskeletal Signaling|||MAPK|||PI3K/Akt/mTOR signaling|||Metabolism|||Apoptosis
Bioactivity
KRAS IN-44 (Compound S2C2M2) is a PDE6D degrader. It inhibits PDE6D-dependent KRAS transport and downstream signaling pathways. Additionally, KRAS IN-44 downregulates EGF-induced phosphorylation of PI3K, AKT, and mTOR. It promotes apoptosis and exhibits antitumor activity against hepatoblastoma.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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MBS6354004-02 5x 0.1 mL
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