BRD4/NAMPT-IN-1
Product Specifications
CAS Number
3049218-28-9
Target
Epigenetic Reader Domain|||NAMPT
Related Pathways
Metabolism|||Chromatin/Epigenetic
Bioactivity
BRD4/NAMPT-IN-1 (Compound A2) exhibits strong inhibitory effects on NAMPT and BRD4, with IC50 values of 35 nM (NAMPT) and 58 nM (BRD4) . This compound significantly suppresses the growth and migration of liver cancer cells while promoting apoptosis. Additionally, BRD4/NAMPT-IN-1 demonstrates potent anticancer activity in HCCLM3 xenograft mouse models without noticeable toxicity.
Smiles
CC=1C2=C(N3C([C@H](CC(NCCCNC(/C=C/C=4C=CC=NC4)=O)=O)N=C2C5=CC=C(Cl)C=C5)=NN=C3C)SC1C
Molecular Formula
C30H30ClN7O2S
Molecular Weight
588.12
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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