II399
Product Specifications
CAS Number
2928480-72-0
Target
Others
Related Pathways
Others
Bioactivity
II399 is a potent and selective dual-substrate inhibitor of NNMT, featuring an unconventional SAM mimic, with a Ki value of 5.9 nM. It exhibits a notable competitive inhibition pattern against NAM and can occupy both the substrate and cofactor binding pockets. II399 shows promise for research in cancer, metabolic, cardiovascular, and neurodegenerative diseases.
Smiles
O[C@H]1[C@H](N2C=3C(C=C2)=C(Cl)N=CN3)C[C@H](CN(CC#CC4=CC(C(N)=O)=CC=C4)C(C)=O)[C@H]1O
Molecular Formula
C24H24ClN5O4
Molecular Weight
481.93
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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