EGFR/c-Met-IN-1
Product Specifications
CAS Number
3020728-68-8
Target
C-Met/HGFR|||EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis
Bioactivity
EGFR/c-Met-IN-1 (compound TS-41) is a dual inhibitor targeting EGFR and c-Met, with IC50 values of 68.1 nM for EGFRL858R and 0.26 nM for c-Met. EGFR/c-Met-IN-1 induces apoptosis and cell cycle arrest in A549-P cells, and reduces phosphorylation of EGFR, c-Met, and downstream AKT. This compound effectively inhibits tumor growth both in vitro and in vivo.
Smiles
O=C(C=C)NC1=CC=2C(=NC=NC2C=C1OC)OC3=CC=C(C=C3F)NC(=O)C=4C(=O)N(C=5C=CC=CC5)N(C4C)C
Molecular Formula
C30H25FN6O5
Molecular Weight
568.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
BZ46064 1 Vial
PLV3-CMV-mCherry-Linker-PKP1 (human) (1Synonymous mutation) -EF1a-Puro
Ask
View Details 