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TrxR-IN-8

Product Specifications

CAS Number

2857180-28-8

Target

Apoptosis|||Reactive Oxygen Species

Related Pathways

Metabolism|||NF-?B|||Apoptosis|||Immunology/Inflammation

Bioactivity

TrxR-IN-8 (Compound 6f) is a selective inhibitor of TrxR with an IC50 of 10.2 ?M. It induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species, reducing intracellular thiols, and lowering the glutathione/glutathione disulfide ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells.

Smiles

[I-].O(C=1C=C(OC)C=2C=3C=CC=CC3C=[N+](C2C1)C)C

Molecular Formula

C16H16INO2

Molecular Weight

381.21

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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