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2-Guanidinobezimidazole

Product Specifications

CAS Number

5418-95-1

Target

NOD-like Receptor (NLR)

Related Pathways

Immunology/Inflammation

Bioactivity

2-Guanidinobenzimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 ?M for His-GFP-NLRP3. It directly binds to the LRR domain of NLRP3, facilitating the assembly and activation of the inflammasome. Additionally, 2-Guanidinobenzimidazole enhances antitumor immunity, inhibits tumor growth, and overcomes resistance to immune checkpoint blockade (ICB) .

Smiles

N=C(N)NC1=NC=2C=CC=CC2N1

Molecular Formula

C8H9N5

Molecular Weight

175.191

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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